Dinna N. Cruz, M.D., M.P.H.
Associate Professor of Medicine
My major areas of interest are acute kidney injury (AKI) and the cardiorenal syndrome (CRS). My research utilizes epidemiology and study of newer biomarkers to understand the mechanisms and factors which predispose patients to developing AKI and CRS, aid in the early recognition of these patients, and subsequently develop effective therapeutic strategies to prevent or ameliorate progression into severe AKI. In addition, I am interested in how AKI contributes to poor clinical outcomes and progressive chronic kidney disease, by studying alterations in glomerular, tubular and endocrine functions in patients after AKI.
Acute kidney injury
Critical care nephrology
Cruz DN, Schmidt-Ott KM, Vescovo G, House AA, Kellum JA, Ronco C, McCullough PA: Pathophysiology of cardiorenal syndrome type 2 in stable chronic heart failure: workgroup statements from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI). Contributions to nephrology 2013, 182:117-136.
Cruz DN, Bagshaw SM, Maisel A, Lewington A, Thadhani R, Chakravarthi R, Murray PT, Mehta RL, Chawla LS: Use of biomarkers to assess prognosis and guide management of patients with acute kidney injury. Contributions to nephrology 2013, 182:45-64.
Cruz DN: Cardiorenal syndrome in critical care: the acute cardiorenal and renocardiac syndromes. Advances in chronic kidney disease 2013, 20(1):56-66.
Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, Jaber BL: World Incidence of AKI: A Meta-Analysis. Clinical journal of the American Society of Nephrology : CJASN 2013, 8(9):1482-1493.
Yeates K, Cruz DN, Finkelstein FO: Re-examination of the Role of Peritoneal Dialysis to Treat Patients with Acute Kidney Injury. Perit Dial Int 2012, 32(3):238-241.
Gaiao S, Finkelstein FO, de Cal M, Ronco C, Cruz DN: Acute kidney injury: are we biased against peritoneal dialysis? Perit Dial Int 2012, 32(3):351-355.
Lameire NH, Bagga A, Cruz DN, De Maeseneer J, Endre Z, Kellum JA, Liu KD, Mehta RL, Pannu N, Van Biesen W et al: Acute kidney injury: an increasing global concern. Lancet 2013, 382(9887):170-179.
Cruz DN, Goh CY, Marenzi G, Corradi V, Ronco C, Perazella MA: Renal Replacement Therapies for Prevention of Radiocontrast-induced Nephropathy: A Systematic Review. Am J Med 2012, 125(1):66-78 e63.
Cruz DN, Gaiao S, Maisel A, Ronco C, Devarajan P: Neutrophil gelatinase-associated lipocalin as a biomarker of cardiovascular disease: a systematic review. Clin Chem Lab Med 2012, 50(9):1533-1545.
Cruz DN, de Geus HR, Bagshaw SM: Biomarker strategies to predict need for renal replacement therapy in acute kidney injury. Semin Dial 2011, 24(2):124-131.
Cruz DN, de Cal M, Piccinni P, Ronco C: Polymyxin-B hemoperfusion and endotoxin removal: lessons from a review of the literature. Contrib Nephrol 2010, 167:77-82.
Cruz DN, Bagshaw SM: Heart-kidney interaction: epidemiology of cardiorenal syndromes. Int J Nephrol 2010, 2011:351291.
Cruz DN, Antonelli M, Fumagalli R, Foltran F, Brienza N, Donati A, Malcangi V, Petrini F, Volta G, Bobbio Pallavicini FM et al: Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA 2009, 301(23):2445-2452.
Bagshaw SM, Cruz DN, Gibney RN, Ronco C: A proposed algorithm for initiation of renal replacement therapy in adult critically ill patients. Crit Care 2009, 13(6):317.
Cruz DN, Perazella MA, Bellomo R, de Cal M, Polanco N, Corradi V, Lentini P, Nalesso F, Ueno T, Ranieri VM et al: Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care 2007, 11(2):R47.