Cynthia M. Miracle, M.D.
Phone : (858)552-8585 ext 7528
My current focus is on factors contributing to the regulation of kidney oxygen consumption with the long term goal to develop a comprehensive kidney wide model for the control of kidney metabolism. I am specifically interested in the interaction between nitric oxide, angiontensin II and the renal alpha-2 adrenergic nerves in the regulation of kidney oxygen consumption. This research is funded by a KO8 from the National Institutes of Health.
Deng A, Miracle CM, Suarez JM, Lortie M, Satriano J, Thomson SC, Munger KA, Blantz RC: Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II. Kidney Int. 2005 Aug; 68(2):723-30.
Deng A, Miracle CM, Lortie M, Satriano J, Gabbai F, Munger KA, Thomson SC, Blantz RC: Kidney oxygen consumption, carbonic anhydrase, and proton secretion. Am J Physiol Renal Physiol. 2006 May; 290:F1009-1015.
Blantz RC, Deng A, Miracle CM, Thomson SC: Regulation of kidney function and metabolism: A question of supply and demand. Trans Clin Climatol Assoc 2007; 118: 23-43.
Miracle CM, Rieg T, Blantz RC, Volker V, Thomson SC: Combined Effects of Carbonic Anhydrase Inhibitor and Adenosine A 1 Receptor Antagonist on Hemodynamic and Tubular Function in the Kidney. Kidney Blood Press Res. 2007 Sep 20;30(6):388-399 [Epub ahead of print]
Miracle CM, Rieg T, Mansoury HA, Vallon V, Thomson SC. Ornithine decarboxylase inhibitor eliminates hyper-responsiveness of the early diabetic proximal tubule to dietary salt. (Submitted for publication)