Robert Parmer, M.D.
Professor of Medicine
Phone : (858)552-8585 ext 7356
Dr. Parmer’s research includes both laboratory-based basic research and patient-oriented clinical investigation, and focuses on studies to better understand the pathophysiologic mechanisms underlying blood pressure regulation and hypertension. Clinical studies focus on autonomic and renal mechanisms of blood pressure regulation, including studies of sympathoadrenal and renal serine protease activity, sodium homeostasis, and renal hemodynamics in hypertension. Basic studies focus on the role of the plasminogen activation system in catecholaminergic/sympathoadrenal function and renal function. Recent studies have included the identification of a novel protein, Plg-RKT, an integral transmembrane protein that serves as a major plasminogen receptor on a variety of cell types and tissues, and which markedly accelerates activation of plasminogen to the active protease plasmin.
Diagnosis and management of essential and secondary forms of hypertension, acute and chronic kidney disease, diabetic nephropathy, hemodialysis, general and ICU nephrology.
- Parmer RJ, Cervenka JH, Stone RA: Baroreflex sensitivity and heredity in essential hypertension. Circulation 85:497-503, 1992.
- Parmer RJ, Xi X-P, Wu HJ, Helman LJ, Petz LN: Secretory protein traffic: chromogranin A contains a dominant targeting signal for the regulated pathway. J Clin Invest 92:1042-1054, 1993.
- Parmer RJ, Stone RA, Cervenka JH: Renal hemodynamics in essential hypertension: racial differences in response to changes in dietary sodium. Hypertension 24:752-757, 1994.
- Parmer RJ, Mahata M, Mahata S, Sebald MT, O'Connor DT, Miles LA: Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway: catecholamine storage vesicles as a reservoir for the rapid release of t-PA. J Biol Chem 272:1976-1982, 1997.
- Parmer RJ, Mahata M, Gong Y, Mahata SK, Jiang Q, O'Connor DT, Xi XP, Miles LA: Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion. J Clin Invest. 106(7):907-15, 2000.
- Jiang Q, Taupenot, Mahata SK, Mahata M, O'Connor DT, Miles LA, Parmer RJ: Proteolytic cleavage of chromogranin A (CgA) by plasmin: selective liberation of a specific bioactive CgA fragment that regulates catecholamine release. J Biol Chem 276: 25022-25029, 2001.
- Timberlake DS, O’Connor DT, Parmer RJ: Molecular genetics of essential hypertension: recent results and emerging strategies. Current Opinion in Nephrology and Hypertension 10:71-79, 2001.
- Jiang Q, Yasothornsrikul S, Taupenot L, Miles LA, Parmer RJ: The local chromaffin cell plasminogen/plasmin system and the regulation of catecholamine secretion. Ann N Y Acad Sci 971:445-9, 2002.
- Miles LA, Hawley SB, Parmer RJ: Chromaffin cell plasminogen receptors. Ann N Y Acad Sci 971:454-9, 2002.
- Wong CM, O'Connor DT, Martinez JA, Kailasam MT, Parmer RJ: Diminished renal kallikrein responses to mineralocorticoid stimulation in African Americans: determinants of an intermediate phenotype for hypertension. Am J Hypertens 16:281-9, 2003.
- Miles LA, Hawley SB, Baik N, Andronicos NM, Castellino FJ, Parmer RJ: Plasminogen receptors: The sine qua non of cell surface plasminogen activation. Frontiers in Bioscience 10:1754-62, 2005.
- Miles LA, Andronicos NM, Baik A, Parmer RJ: Cell surface actin binds plasminogen and modulates catecholamine release from catecholaminergic cells. Journal of Neuroscience 26:13017-13024, 2006.
- Andronicos NM, Chen EI, Baik N, Bai H, Parmer CM, Kiosses WB, Kamps MP, Yates JR, III, Parmer RJ, Miles LA: Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation. Blood 18;115(7):1319-30, 2010.
- Jiang Q, Gingles NA, Olivier MA, Miles LA, Parmer RJ: The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles. Blood 117(26):7155-63, 2011.
- Bai H, Baik N, Kiosses WB, Krajewski S, Miles LA, Parmer RJ: The novel plasminogen receptor, Plasminogen Receptor KT (Plg-RKT), regulates catecholamine release. J Biol Chem 286(38):33125-33, 2011.
- Nangia S, Bai H, Kiosses WB, Vallon V, Miles LA, Parmer RJ: Nephron expression and distribution of the plasminogen receptor, Plg-RKT, and colocalization with ENaC and uPAR, in murine kidney. J Am Soc Neph 22:527A, 2011.
- Miles LA, Andronicos NM, Chen EI, Baik N, Bai H, Parmer CM, Lighvani S, Nangia S, Kiosses WB, Kamps MP, Yates JR, III, Parmer RJ: Identification of the novel plasminogen receptor, Plg-RKT. In: Proteomics/Book 1: Human Diseases and Protein Functions, ISBN 978-953-307-832-8, Man TK and Flores RJ (Eds.), Intech, Chapter 10: 219-238, 2012.
- Bai H, Nangia S, Parmer RJ: The plasminogen activation system and the regulation of catecholaminergic function. J Biomed Biotechnol 2012:721657-70, 2012. PMID 23097598.
- Miles LA and Parmer RJ: Plasminogen Receptors: The First Quarter Century. Seminars in Thrombosis and Hemostasis. In Press, 2013.