Division of Nephrology-Hypertension

Satish P. RamachandraRao, Ph.D.

Assistant Professor of Medicine
Curriculum Vitae

Phone: (619) 543-7298
E-mail: satishrao@ucsd.edu
Location: CTF-C/Hillcrest
Room: 205B
Mail Code: 8342
Mailing Address: 200 W. Arbor Drive #8342
San Diego, CA 92103-8342
Fax: (619) 543-7769

Research Interests

To make urine from the glomerular filtrate in the kidney, given the extent of energy-dependent active processes of reabsorption and secretion that take place, the integrity of renal mitochondrial structure and function is critical to normal kidney function. I am interested in understanding the molecular mechanism(s) by which mitochondrial dysfunction contributes to kidney failure among persons with kidney disease. My research has specifically focused on developing and utilizing novel tools – exosomes – biologically active nanoparticles as biomarker source to understand 1. Kidney mitochondrial structure and function in normal health 2. How it alters in various kidney disease etiologies. For this purpose we use exosomes from three sources namely 1. Patient urine, 2. Blood and urine from animal models and 3. Conditioned media from tissue culture experiments. We analyze their contents to study how mitochondrial function affects kidney disease outcome and vice versa.

Selected Publications

Satish P. RamachandraRao, Richard Wassell, M. Alexander Shaw & Kumar Sharma. (2007) Expression Profiling of Human Mesangial Cell Sub-Proteomes Reveals a Role for Calmodulin in Glucose Uptake; Am J Physiol. Renal Physiol; 292:1182-1189.

Sharma K, Lee S, Han S, Lee S, Francos B, McCue P, Wassell R, Shaw MA, RamachandraRao SP. (2005). Two-dimensional fluorescence difference gel electrophoresis analysis of the urine proteome in human diabetic nephropathy. Proteomics. 5, 2648-2655.

Surolia N, Satish P. RamachandraRao, Surolia A. (2002) Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy. Bioessays. 24,192-196.

Satish P.R., Surolia A. (2001) Exploiting lectin affinity chromatography in clinical diagnosis. J Biochem Biophys Methods. 49, 625-640.

Suneetha, L.M., Satish, P.R., Korula, R.J., Suneetha, S.K., Job, C.K. and Balasubramanian, A.S. (1998) Mycobacterium leprae binds to a 25 -kDa phosphorylated glycoprotein of human peripheral nerve. Neurochem. Res. 23, 909-913.