Division of Nephrology-Hypertension

Mita M. Shah, M.D.

Associate Professor of Medicine
Curriculum Vitae

E-mail : mshah@ucsd.edu
Location : Leichtag Bldg
Room : 3268
Mail Code : 0693
Mailing Address : 9500 Gilman Drive #0693
La Jolla, CA 92093-0693

Clinical and Research Interests

I am primarily interested in kidney transplantation.  I am involved in all aspects of clinical transplantation, from the pre-transplant evaluation to the long-term maintenance of kidney allograft function.  My research is currently focused on developing novel biomarkers for the evaluation of graft quality of deceased donor kidneys.  I am also actively involved in teaching medical students, residents and nephrology fellows the various aspects of kidney transplant. 
My prior research focused on how the collecting system of the kidney develops. This research integrated in vitro models that recapitulate kidney collecting system development with in vivo model systems.  Using this approach, I was able to demonstrate that various combinations of growth factor plus differentially sulfated heparan sulfate proteoglycans were intimately involved in modulating the distinct processes of kidney development. 

Publications

Peer Reviewed Articles

Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush KT, Esko JD, Nigam SK.  Growth factor 
   dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan   
   sulfate.  Dev Biol. 2011 356(1):19-27.

Tee JB, Choi Y, Shah MM, Dnyanmote A, Sweeney DE, Gallegos TF, Johkura K, Ito C, Bush  
   KT, Nigam SK.  Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-
   independent ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2010 347(2):337-47.

Shah MM, Sakurai H, Sweeney DE, Gallegos TF, Bush KT, Esko JD, Nigam SK.  Hs2st  
   mediated kidney mesenchyme induction regulates early ureteric bud branching.  Dev Biol.
   2010 339(2):354-65. 

Shah MM, Tee JB, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney DE, Gallegos TF,Johkura
   K, Rosines E, Kouznetsova V, Rose DW, Bush KT, Sakurai H, Nigam SK.  The instructive
   role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its
   potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol. 2009;
   297:F1330-41.

Choi Y, Tee JB, Gallegos TF, Shah MM, Oishi H, Sakurai H, Kitamura S, Wu W, Bush KT,
   Nigam SK. Neuropeptide Y functions as a facilitator of GDNF-induced budding of the
   Wolffian duct. Development. 2009; 136:4213-24.

Rosines E, Sampogna RV, Johkura K, Vaughn DA, Choi Y, Sakurai H, Shah MM, Nigam SK.   
   Staged in vitro reconstitution and implantation of engineered rat kidney tissue.  PNAS. 2007; 
104(52):20938-43.

Shah MM*, Steer DL*, Bush KT, Stuart RO, Sampogna RV, Meyer TN,
   Schwesinger C, Bai X, Esko JD, Nigam SK.  Regulation of ureteric bud branching 
   morphogenesis by sulfated proteoglycans in the developing kidney.  Developmental Biology.  
   2004; 272(2):310-27.  (*co-first author);

Meyer TN, Schwesinger C, Bush KT, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL,   
   Nigam SK.  Spatiotemporal regulation of morphogenetic molecules during in vitro branching
   of the isolated ureteric bud: toward a model of branching through budding in the developing
   kidney. Developmental Biology.  2004; 275(1):44-67.

Shah MM, Sampogna RV, Sakurai H, Bush KT, Nigam SK.  Branching morphogenesis and 
   kidney disease.  Development.  2004; 131(7):1449-62.

Shah MM, Li Y, Christensen RD.  Effects of perinatal zidovudine on hematopoiesis: a
   comparison of effects on progenitors from human fetuses versus mothers.  AIDS.  
   1996;10(11):1239-47.   

Li Y, Ohls RK, Rosa C, Shah M, Richards DS, Christensen RD.  Maternal and umbilical serum
   concentrations of granulocyte-colony stimulating factor and its messenger RNA during clinical
   chorioamnionitis. Obstetrics and Gynecology. 1995;86:428-432.

Invited Reviews/Book Chapters

Nigam SK, and Shah MM. How does the ureteric bud branch? J Am Soc Nephrol. 2009;
   20:1465-9.

Shah MM, Steer DL, Sweeny DE, Nigam SK.  Development of the Kidney.  In: Inborn Errors of
   Development, Ed. Wynshaw-Boris A; 2008 (Book Chapter)