Kumar Sharma, M.D., F.A.H.A.
Professor of Medicine
Phone : (858)822-0870
Kumar Sharma is Professor of Medicine at the University of California, San Diego and serves as the Director of the Institute for Metabolomic Medicine and the Center for Renal Translational Medicine. He is Founding Chair of the ISN Nexus Symposium Core Committee, an international translational symposium and has co-organized an NIH Mitochondrial Workshop and many international symposiums. He completed his MD and Internal Medicine residency at the Albert Einstein College of Medicine in New York and his clinical and research nephrology fellowship was completed at the University of Pennsylvania. His research has been continuously funded by the NIDDK, JDRF and the ADA. Dr. Sharma has had a dedicated and consistent translational approach for diabetic complications for the past 25 years and has expertise in developing phenotype analysis using imaging, molecular and biochemical methods, genomics, microarray, proteomics and metabolomics. He has over 150 peer-reviewed original and review articles in top-notch journals (Nature Medicine, Journal of Clinical Investigation, Cell Metabolism) and has been the recipient of several awards. His recent studies have employed novel imaging and systems biology approaches to understand novel mechanisms related to obesity-related complications, diabetic kidney disease and novel therapies. His major focus in the past few years has been to develop novel biomarkers for chronic kidney disease and diabetic complications. In particular, recent metabolomic and mitochondrial studies in animal models and humans have led to novel insights and new theories into the pathogenesis of diabetic complications and the role of the kidney in energy metabolism.
Dr. Sharma has maintained a strong clinical practice with a focus on patients with type 1 and type 2 diabetes and kidney disease. He has conducted NIH-funded and industry supported investigator-initated clinical trials. He has a major interest in the development of clinical biomarkers of kidney disease progression.
Ziyadeh FN., Hoffman BB., Han DC., Iglesias-De La Cruz MC., Hong SW., Isono M., Chen S., McGowan TA., Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti-transforming growth factor-beta antibody in db/db diabetic mice. Proceedings of the National Academy of Sciences-USA. 97:8015-8020, 2000. Press release.
Sharma, K., Deelman, L., Madesh, M. Kurz, B., Ciccone, E., Siva, S., Hu, T., Zhu, Y., Wang, L., Henning, R., Ma, X., Hajnoczky, G. Involvement of Transforming Growth Factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. American Journal of Physiology, Renal Fluid and Electrolyte, 285:F1258-F1270, 2003
Susztak, K., Bottinger, E.P, Novetsky, A., Liang, D., Zhu, Y, Ciccone, E., Wu, D., Dunn, S., McCue, P., Sharma, K. Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes, 53:784-794 2004.
Susztak, K, Ciccone, E, McCue, P., Sharma, K, Böttinger, E. Multiple Metabolic Hits Converge on CD36 Scavenger Receptor as Novel Mediator of Tubular Epithelial Apoptosis in Diabetic Nephropathy. Public Library of Science, 2:0152-0161, e45, 2005. Press release.
Sharma, K, Lee, S-H, Han, S, Lee, S, Francos, B, McCue, P, Shaw, M.A., RamachandraRao, S, Two dimensional fluorescence difference gel electrophoresis (DIGE) analysis of the urine proteome in human diabetic nephropathy. Proteomics 5:2648 – 2655, 2005.
Zhu, Y., Usui, H., Sharma. K. Regulation of Transforming Growth Factorb-beta in Diabetic Nephropathy: Implications for Treatment in Diabetic Nephropathy. Seminars in Nephrology, invited review Mar;27(2):153-60, 2007