Division of Nephrology-Hypertension

Prabhleen Singh, M.D., M.P.H.

Assistant Professor of Medicine
Curriculum Vitae

E-mail : p1singh@ucsd.edu
Location : VAMC (SD)
Mail Code : 9111H
Mailing Address : 9500 Gilman Drive # 9111H
La Jolla, CA 92093-9111
Phone : (858)552-8585
Fax : (858)552-7549

Research Interests

Dr. Sheena Singh’s interest has been to examine the key renal hemodynamic and metabolic adaptations at the onset of acute and chronic kidney injury, which play an important role in the pathophysiology of disease progression. I have expertise in in-vivo physiological techniques to measure renal hemodynamics, renal micropuncture to assess glomerular and tubular function at a single nephron and whole kidney level, and in-vivo kidney oxygen consumption. I combine these with cellular/molecular biology techniques in mitochondrial bioenergetics, immunostaining and transmission electron microscopy for a comprehensive investigative approach. My research focuses on the coupling of tubular transport and metabolism and novel regulators of these processes such as HIF-1a and AMPK. Current projects include assessment of intrarenal hemodynamics along with determinants of oxygen utilization and mitochondrial function in specific tubular segments in rodent models of acute kidney injury including ischemia reperfusion and cecal ligation and puncture model of sepsis and models of diabetic and non-diabetic chronic kidney disease. These research investigations have been supported in the past by National Kidney Foundation Research awards, pilot and feasibility grant from the NIH funded O’Brien Center for Acute Kidney Injury Research, and NIH K08 Mentored Career Development Award and currently by VA Merit Award (R01 equivalent in the VA research portfolio), NIH R03 award and American Diabetes Association Award.

Clinical Interests

Include ICU nephrology and acute kidney injury.

Selected publications

Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P.InteractionsbetweenHIF-1α andAMPKin theregulationofcellular hypoxiaadaptationin chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 1;309(5) PMID: 26136559

Prabhleen Singh, Scott C. Thomson. Renal homeostasis and tubuloglomerular feedback Curr Opin Nephrol Hypertens. 2010 Jan;19(1):59-64.

Prabhleen Singh, Aihua Deng, Roland C. Blantz, Scott C. Thomson. Unexpected effect of angiotensin AT-1 receptor blockade on tubuloglomerular feedback in early subtotal nephrectomy Am J Physiol Renal Physiol. 2009 May;296(5):F1158-65. Epub 2009 Feb 11.

Aihua Deng, Tong Tang, Prabhleen Singh, Chen Wang, Joseph Satriano, Scott C.Thomson, Roland C. Blantz. Regulation of oxygen utilization by angiotensin II in chronic kidney disease. Kidney Int. 2009 Jan;75(2):197-204. Epub 2008 Sep 24.

Mario Ruiz, Prabhleen Singh, Scott C. Thomson, Karen Munger, Roland C. Blantz, Francis B. Gabbai. L-arginine induced glomerular hyperfiltration response: the roles of Insulin and Angiotensin II Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1744-51. Epub 2008 Mar 19.

Prabhleen Singh, Michelle L. Robbin, Mark E. Lockhart, and Michael Allon. Clinically Immature Arteriovenous Hemodialysis Fistulas: Effect of Ultrasound on Salvage Radiology. 2008 Jan; 246(1): 299-305. Epub 2007 Nov 8

Prabhleen Singh, Aihua Deng, Mathew R. Weir, Roland C. Blantz. The balance of angiotensin II and nitric oxide in kidney diseases Curr Opin Nephrol Hypertens. 2008 Jan; 17(1): 51-56.