Scott Thomson, M.D.
Professor of Medicine
Phone : (858) 552-7528
Dr. Thomson conducts research into the autoregulation of renal function with particular emphasis on glomerular hemodynamics and on tubuloglomerular feedback from the macula densa to the glomerular microvasculature in the control of glomerular filtration. In order to study the operational behavior of this tubuloglomerular feedback system, we have implemented methods for measuring flow in unobstructed free-flowing single rat nephrons in micropuncture experiments and for quantifying the efficiency of the tubuloglomerular feedback response when flow is perturbed. Projects are underway to elucidate the basic physiologic mechanism of tubuloglomerular feedback and to examine the role of altered proximal tubular function as a cause of glomerular hyperfiltration in experimental diabetes. This work employs a variety of biomedical research methods as adjuncts to micropuncture. But the lab remains centered around renal micropuncture, which requires Dr. Thomson to perform most experiments himself. This research is funded by an RO1 from the National Institutes of Health and a Merit Review grant from the VA Research Service.
Dr. Thomson's nephrology practice includes: ICU nephrology (acute dialysis and CRRT in the critically ill), transplant nephrology, general nephrology, hypertension, clinical fluid-electrolyte and acid-base physiology and apheresis.
Thomson SC, Bachmann S, Bostanjoglo M, Ecelbarger CA, Peterson OW, Schwartz D, Bao D, Blantz RC. Temporal adjustment of the juxtaglomerular apparatus during sustained inhibition of proximal reabsorption. J Clin Invest 104:1149-1158, 1999.
Thomson SC, Bao D, Deng A, Vallon V. Adenosine formed by 5'-nucleotidase mediates tubuloglomerular feedback. J Clin Invest 106(2):289-98, 2000.
Thomson SC. Deng A, Bao D, Satriano J, Blantz RC, Vallon V. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. J Clin Invest. 107:217-224, 2001.
Thomson SC, Vallon V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol Renal Physiol. 2004 Jan;286(1):F8-15.
Thomson SC, Deng A, Wead L, Richter K. Blantz RC, Vallon V. Linking Dietary Salt and Proximal Reabsorption; An Unexpected Role for Angiotensin II. J Clin Invest. 2006 Apr;116(4):1110-6.