Volker Vallon, M.D.
Professor of Medicine and Pharmacology
Phone : (858)552-8585 ext 5945
Dr. Vallon's research has characterized the roles played by a variety of channels, transporters, receptors and signalling molecules in the physiology, pharmacology and pathophysiology of the kidney. He aims to integrate aspects of vascular, glomerular and tubular function to gain a more complete understanding of the physiology and pharmacology of the kidney as well as the pathophysiology of arterial hypertension and of the early diabetic kidney. His work is a blend of physiology, molecular biology and pharmacology, and particularly uses gene-targeted mouse models, including micropuncture studies on the level of the single nephron, to dissect the contributions of specific genes.
Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K, Lang F (2005) KCNQ1 dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci U S A, 102:17864-17869.
Thomson SC, Deng A, Wead L, Richter K, Blantz RC, Vallon V (2006) An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption. J Clin Invest, 116:110-116.
Vallon V, Muhlbauer B, Osswald H (2006) Adenosine and kidney function. Physiol Rev, 86:901-40.
Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V (2006) (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev, 86:1151-1178.
Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V (2007) Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J 21:3717-26.
Zhang W, Xia, X, Reisenauer MR, Rieg T, Lang F, Kuhl D, Vallon V, Kone B (2007) Aldosterone-induced SGK1 phosphorylates AF9 and relieves Dot1a-AF9-mediated transcriptional repression of ENaCα. J Clin Invest, 117:773-783.
Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, and Nigam SK (2008). Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol, 19:1732-1740.
Vallon V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B, Cunard R, and Stockand J (2009) Thiazolidinedione-induced fluid retention is independent of collecting duct αENaC activity. J Am Soc Nephrol, 20:721-729.
Vallon V, Schroth J, Satriano J, Blantz RC, Thomson S, Rieg T (2009) Adenosine A1 receptors determine glomerular hyperfiltration and the salt paradox in early diabetes mellitus. Nephron Physiol, 111:30-38.
Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V (2010) Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J 24:2056-65.
Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V (2010) Adenyly cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in renal inner medulla. J Am Soc Nephrol, 21:2059-2068.
Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T (2011) SGLT2 mediates glucose reabsorption in early proximal tubule. J Am Soc Nephrol, 22:104-112.
Vallon V (2011) The proximal tubule in the pathophysiology of the diabetic kidney. Am J Physiol Regul Integr Comp Physiol, 300:R1009-R1022.
Vallon V, Rieg T (2011). Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system. Am J Physiol Renal Physiol, 301:F463-F475.